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Solubility and safety of polyethylene glycol

2021-11-02 08:18:38
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solubility


Polyethylene glycol is soluble in alcohols, alcohol-silicon mixtures, dialcohols, esters, ketones, aromatic hydrocarbons, nitroalkanes and most of the high properties of organic solvents. It is insoluble in fatty hydrocarbons, cycloalkanes and other low and sexual organic solvents. The solubility of polyethylene glycol is related to its relative molecular mass grade and temperature. In addition, peg is soluble in low - grade aldehydes, amines, organic acids, anhydrides and polymers. But it is insoluble in canola oil, mineral oil and other compounds containing long hydrocarbon chains.


Liquid polyethylene glycol (PEG), such as PEG-400, has good solubility in a variety of pharmaceutical raw materials and is of great use in clinical practice.


use


Polyethylene glycol and polyethylene glycol fatty acid esters are widely used in the cosmetic and pharmaceutical industries. Because PEG has water-soluble, non-volatile, physiological inertia, mild, lubricity, wettability, softness, comfortable after use and other advantages. Polyethylene glycol can be selected from different molecular weight levels to change the viscosity, hygroscopicity and structure of the product. Polyethylene glycol (Mr2000) is used as a wetting agent and consistency regulator in comparison to its molecular weight, in creams, lotions, toothpastes and shaving creams, and in uncleaned hair care products to give hair a silken shine. Polyethylene glycol (Mr>2000) is suitable for lipstick, deodorant stick, soap, shaving soap, foundation, beauty cosmetics, etc. Polyethylene glycol is also used as a suspending agent and thickener in cleaning agents. In the pharmaceutical industry, it is used as a base for ointments, emulsions, ointments, detergents, and suppositories. PolyethyleneGlycolNF, Dowchemicalco.) is more suitable for food and medicine by PolyethyleneGlycolNF and poly (propylene glycol) similar to polyethylene glycol application.




Ann Quan sex


Polyethylene glycol in food chemicals is approved directly or indirectly as a food additive under the Food Additive Supplement of the Federal Food and Cosmetic Regulations. In 1985, FAO/WHO set the ADI value at 0~10mg/kg. GRAS(FDA, §172.820, 1985).


Acute oral toxicity (mice) LD5033-35g /kg, intraperitoneal toxicity LD5010-13g /kg. Does not irritate eyes, will not cause skin irritation and allergy.


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